Metabolic Regulation and Obesity
Signal Transduction/Hormone Action
Islet Biology and Immunology
Category(ies) of Research
Descriptor of Research
Research in my group is focused on the role of fatty acid uptake and utilization in the cellular response to stress and how this influences development of abnormalities linked to Diabetes and the metabolic syndrome. In particular we are interested in how these processes are impacted by alterations in the cellular trafficking and turnover of the membrane protein CD36, which has been implicated in complications of insulin resistance. On the translational level we are interested in studying the functional impact of polymorphisms in the CD36 gene and how they can impact individual variability of lipid utilization and susceptibility to metabolic disease.