Category(ies) of Research
Descriptor of Research
Insulin Mediated Pseudoacromegaly (IMPA) is an extremely rare disorder of insulin resistance. Patients affected with this condition have high blood sugar, obesity, and very tall stature. Women with this disease often have excessive body hair and irregular menstrual cycles. Patient with IMPA have physical signs of growth hormone excess (gigantism or acromegaly), however their growth hormone levels are normal. However, patients with IMPA have extremely high insulin levels. Therefore, IMPA is classified as an insulin resistance syndrome. Thus far there is no known genetic or molecular cause of this disease.
Most other known genetic insulin resistance syndromes are associated with short stature. However, individuals with IMPA exhibit signs of tall stature and overgrowth. Therefore, it is hypothesized that IMPA results from a downstream defect in insulin signaling. As a result, the glucose lowering ability of insulin is impaired while the growth promoting ability of insulin enhanced.
Our lab is focused on pursuing the genetic and molecular underpinnings of IMPA in order to shed light on the basic biology insulin resistance and secretion.
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