Signal Transduction/Hormone Action
Islet Biology and Immunology
Category(ies) of Research
Descriptor of Research
Some of the work in Dr. Murphy’s lab intersects with studies on diabetes. Dr. Murphy’s discovery of the Batf3 transcription factor’s control of the development of the cross-presenting CD8a+ dendritic cell subset has led to analysis of the role this cell plays in several settings of infection and autoimmunity. In particular, after backcrossing the Batf3-/- mice onto the non-obese diabetic (NOD) genetic background, in collaboration with Dr. Emil Unanue, we are now finding a requirement for this subset of dendritic cell in development of the autoimmune response in NOD mice.