Gretchen A. Meyer, PhD

Gretchen A. Meyer, PhD

Associate Professor of Physical Therapy, Neurology, Orthopaedic Surgery

Research Interest


Signal Transduction/Hormone Action

Category(ies) of Research


Descriptor of Research

In Type 2 Diabetes, the accumulation of ectopic fat (intermuscular adipose tissue (IMAT)) in muscles of the lower limb is highly correlated with poor glucose handling, insulin resistance and reductions in muscle strength that contribute to functional limitations and disability. My lab is investigating the signals that drive the formation of IMAT and the mechanisms by which IMAT-muscle cross-talk regulates muscle dysfunction in diabetes. We hypothesize that IMAT accumulation can be used therapeutically both as an early biomarker to indicate the onset of peripheral neuropathy and as a therapeutic target where IMAT-muscle cross-talk can be modulated by sympathetic stimulation. These studies will contribute to our understanding of how to best design interventions to improve muscle performance and increase mobility and activity, keys to managing diabetes.

Program in Physical Therapy