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Descriptor of Research
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease (CKD) and end stage renal disease (ESRD) that require renal replacement therapy with dialysis or transplantation. Albuminuria is the cardinal sign of diabetic nephropathy, the quantity of albuminuria correlates well with the different stages of DN and nephrotic range proteinuria is an ominous sign for progression to ESRD. Albuminuria is believed to be more than a sign of DN, as albuminuria may contribute directly to pathologic changes that lead to ESRD. In vitro studies showed that albumin overload in tubular cells was shown to induce pro-inflammatory and pro-fibrotic factors, which may lead to tubular atrophy, interstitial inflammation and fibrosis encountered in kidneys of patients with advanced DN and heavy albuminuria. Our goal is to study the contribution of albuminuria to kidney disease progression in vivo using proteinuric animal models, including models of DN.