Metabolic Regulation and Obesity
Signal Transduction/Hormone Action
Category(ies) of Research
Descriptor of Research
Dr. Mann’s work in the area of diabetes and metabolism related research has focused primarily in the area of the impact of the metabolic syndrome and obesity on heart failure. ¹² His group has shown that the prevalence of metabolic syndrome is high in patients with systolic heart failure and that mortality was lower in patients with metabolic syndrome compared to those without, in keeping with the obesity paradox.¹ In a follow on study, Dr. Mann’s group demonstrated that weight loss in a small group of patients with systolic heart failure did not have any effect on the quality of life.² Since coming to Washington University, Dr. Mann has collaborated with Dr. Lindman to demonstrate that cardiac remodeling is attenuated in diabetic patients who undergo aortic valve replacement for aortic stenosis.³ More recently Dr. Mann has obtained NIH grant support to study the role of SALsalate in patients with diastolic heart failure in type 2 diabetes (1U10HL 110309-01).
1. Hassan SA, Deswal A, Bozkurt B, Aguilar D, Mann DL, Pritchett AM. The metabolic syndrome and mortality in an ethnically diverse heart failure population. J. Card Fail. 14, 590-595 (2008).
2. Pritchett AM, Foreyt JP, Mann DL. Treatment of the metabolic syndrome: the impact of lifestyle modification. Curr. Atherosc/er. Rep. 7, 95-102 (2005).
3. Lindman BR, Arnold SV, Madrazo JA, Zajarias A, Johnson SN, Perez JE, Mann DL. The adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. Gire. Heart Fail. 4, 286-292 (2011).