Metabolic Regulation and Obesity
Signal Transaction/Hormone Action
Category(ies) of Research
Descriptor of Research
We are interested in the effects of a protein called lipin 1 on liver metabolism in health and disease. Our basic science program is aimed at understanding the molecular mechanisms whereby lipin impacts energy metabolism by using strategies to genetically activate, deactivate, or selectively mutate lipin activity in mice and cultured cells. Through collaborations with other investigators conducting clinical studies, we are also quantifying the expression of lipin and its target genes involved in energy metabolism in normal and diseased liver.